Gut Microbiome

About this trial

The primary objective of the study is to determine a change in the gut microbiome (GM) measured before and after neo-adjuvant chemotherapy or chemoradiation for early-stage locally advanced Breast or GI cancers and to examine the association of this change in the GM with pathological response at the time of surgery.
Blood and stool samples will be collected before commencing neo-adjuvant treatment, after completion of neo-adjuvant treatment and in 6 six months after completion of neoadjuvant treatment.

Patient Profile

Patients with Breast Cancer – all subtypes (HER-2 positive, ER and PR positive and TNBC) treated with neoadjuvant treatment including monoclonal antibodies.
Patients with Rectal Cancer treated with neoadjuvant therapy.
Patients Oesophageal Cancer treated with a neoadjuvant approach including gastro-oesophageal junctional carcinoma.

Where’s this trial being run?

Beaumont Hospital

Can I join this study / trial?

The first step we recommend is to talk to your doctor or the cancer trials team at your hospital. You can find contact details for cancer trials research units in Ireland here.

It’s also a good idea to print this page and bring it with you to your appointment. It can help guide the conversation and remind you of what to ask. You may also want to talk to your family or friends about your options, as they can offer support as you make decisions.

For more detailed information

Click Here

Questions?

Here’s a list of questions you may have for your doctor or local cancer research team.

Questions

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Summary Data

Name:	Gut Microbiome
Number:	24-25
Full Title:	A prospective observational study investigating the impact of the gut microbiome constitution on the response to neo-adjuvant chemotherapy and neo-adjuvant chemo-radiation in early-stage breast cancers and early-stage gastrointestinal cancers.

Principal Investigator:	Professor Bryan Hennessy
Type:	Collaborative
Sponsor:	Beaumont Hospital
Recruitment Started:	Global: n/a Ireland: April 2023

Global Recruitment Target:	n/a
Ireland Recruitment Target:	120