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Cancer Trials Ireland > Cancer Trials > Lung

DSSG Group: Lung

TACTI-004

Name No. For Patients with Purpose
TACTI-004 24-20

With  Advanced/Metastatic Non Small Cell Lung Cancer

The purpose of this study is to compare eftilagimod alfa (efti) in combination with pembrolizumab and chemotherapy versus placebo in combination with pembrolizumab and chemotherapy among adults with metastatic non-small cell lung cancer (NSCLC).

HARMONi-3

Name No. For Patients with Purpose
HARMONi-3 24-24

Metastatic non-small cell lung cancer

The purpose of this phase 3 clinical trial is to measure overall survival (OS) and safety of ivonescimab when combined with chemotherapy compared to pembrolizumab combined with chemotherapy.

V940-002

Name No. For Patients with Purpose
V940-002 24-51

Resected Stage II, IIIA,IIIB (N2) Non-Small Cell Lung Cancer.

The purpose of the study is to measure which of the arms of patients (i.e. patient on the Adjuvant V940 (mRNA-4157) Plus Pembrolizumab or Adjuvant Placebo Plus Pembrolizumab) has a better disease free survival outcome (time from starting the study to any recurrence (local, locoregional, regional or distant), occurrence of new primary NSCLC, as assessed by the investigator, or death due to any cause).

The study will also measure other parameters such as the overall survival of the patients, lung cancer specific survival, if patients experience any adverse events and patients Quality of Life while participating.

22-23 NeoCOAST-2

Name No. For Patients with Purpose
22-23 NeoCOAST-2 22-23

Early-Stage (II to IIIA) Non-small Cell Lung Cancer

The purpose is to evaluate pathologic complete response in patients treated with Durvalumab with Oleclumab or Monalizumab. Also safety and tolerability of Durvalumab.

Krystal-7

Name No. For Patients with Purpose
Krystal-7 22-07

Patients with Advanced Non-Small Cell Lung Cancer with KRAS G12C Mutation

This Phase 2 study will evaluate the efficacy and safety of MRTX849 on its own and in combination with pembrolizumab.

The Phase 3 portion of the study compares the efficacy of Adagrasib in combination with pembrolizumab versus pembrolizumab plus chemotherapy

SOURCE – LUNG: Stereotactic Ablative Radiation Therapy Of Ultracentral Lung Tumours

Name No. For Patients with Purpose
SOURCE – LUNG: Stereotactic Ablative Radiation Therapy Of Ultracentral Lung Tumours 18-33

inoperable, early stage, high-risk ultracentrally located lung tumours.

The purpose of the study is to determine the safety of the radiation therapy treatment regimen in terms of side effects experienced within one year after treatment which are related to the radiation therapy.