CLL18 / MOIRAI

About this trial

The CLL18 (MOIRAI) trial is testing different combinations of cancer drugs to treat chronic lymphocytic leukemia (CLL) in people who haven’t had treatment before. It compares fixed-duration treatments with a personalized approach that stops treatment early if the cancer becomes undetectable. The goal is to find the most effective and safest way to treat CLL while minimizing side effects and improving quality of life.

Patient Profile

Perspective patients must have chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) and have never received treatment for it. They need to have active disease that requires treatment, based on standard medical guidelines. These potential participants must be healthy enough overall, with suitable blood counts and organ function, to safely receive the study medications.

Where’s this trial being run?

Beaumont Hospital, Cork University Hospital, St James’s Hospital, University Hospital Limerick, University Hospital Galway, University Hospital Waterford, and Mater Misericordiae University Hospital

Can I join this study / trial?

The first step we recommend is to talk to your doctor or the cancer trials team at your hospital. You can find contact details for cancer trials research units in Ireland here.

It’s also a good idea to print this page and bring it with you to your appointment. It can help guide the conversation and remind you of what to ask. You may also want to talk to your family or friends about your options, as they can offer support as you make decisions.

For more detailed information

Click Here

Questions?

Here’s a list of questions you may have for your doctor or local cancer research team.

Questions

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Summary Data

Name:	CLL18 / MOIRAI
Number:	24-34
Full Title:	CLL18 / MOIRAI: an international phase-III trial aiming to establish measurement of individual residual disease for adjustment of treatment duration to improve outcomes in first-line treatment of CLL/SLL

Principal Investigator:	Prof Patrick Thornton (Beaumont Hospital)
Type:	Collaborative
Sponsor:	University of Cologne
Recruitment Started:	Global: Jan 2024 Ireland: Oct 2025

Global Recruitment Target:
Ireland Recruitment Target:	95