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Cancer Trials Ireland > Cancer Trials > Lymphoma & blood cancers > Chronic Lymphocytic Leukaemia (CLL)

DSSG Group: Chronic Lymphocytic Leukaemia (CLL)

CLL18 / MOIRAI

Name No. For Patients with Purpose
CLL18 / MOIRAI 24-34

previously untreated chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL)

The CLL18 (MOIRAI) trial is testing different combinations of cancer drugs to treat chronic lymphocytic leukemia (CLL) in people who haven’t had treatment before. It compares fixed-duration treatments with a personalized approach that stops treatment early if the cancer becomes undetectable. The goal is to find the most effective and safest way to treat CLL while minimizing side effects and improving quality of life.

LOXO-BTK-20022

Name No. For Patients with Purpose
LOXO-BTK-20022 21-44

Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
The purpose of this study is to compare the efficacy and safety of fixed duration pirtobruitinib (LOXO-305) with VR (Arm A) compared to VR alone (Arm B) in patients with CLL/SLL who have been previously treated with at least one prior line of therapy. Participation could last up to five years.

MK2140-006 or Waveline 006

Name No. For Patients with Purpose
MK2140-006 or Waveline 006 23-16

Selected Non-Hodgkin Lymphomas and Chronic Lymphocytic Leukemia

The purpose of this study is to assess the safety and tolerability of zilovertamab vedotin as monotherapy and in combination in participants with select B-cell lymphomas including mantle cell lymphoma (MCL), Richter’s transformation lymphoma (RTL), follicular lymphoma (FL), and chronic lymphocytic leukemia (CLL). This study will also evaluate zilovertamab vedotin as monotherapy and in combination with respect to objective response rate.