DSSG Group: Gastrointestinal

Patients with histologically proven adenocarcinoma of the GEJ type II

The objective of this study is to compare transthoracic esophagectomy versus transhiatal extended gastrectomy inpatients in patients with adenocarcinoma of the gastroesophageal junction (GEJ) type II

Participants must be 18 years or older and have undergone surgical resection for curatively intended treatment of oesophageal or gastric cancer (adenocarcinoma and squamous cell carcinoma) with or without neoadjuvant/adjuvant chemotherapy or radiotherapy or immunotherapy (or in combination). Additional criteria apply.

The SARONG-II study will investigate if regular radiological scans can lead to earlier detection of a cancer returning, at a stage when it may be more readily treatable. This means that participants who agree to take part will be allocated by chance to either more intensive imaging surveillance (including regular radiological scans and a camera test (endoscopy) or clinical follow-up.
The main aim of this study will be to determine whether earlier detection of cancer through more intensive follow-up results in improved survival and better quality of life for patients with oesophagus or stomach cancer. The investigators anticipate the results of the study may have significant practice-changing impact for patients undergoing follow-up after surgery for oesophagus and stomach cancer.

Participants must be 18 years or older and have been diagnosed with pancreatic cancer and been referred for chemotherapy at SVUH before potentially having surgery. Additional criteria applies.

Participants will participate in a 12 week multi-modal nutritional care package while undergoing standard chemotherapy for pancreatic cancer at SVUH. The care package consists of diet, supplements, daily step target and dietitian and physiotherapist appointments. Participants will be followed up for 6 months.

Advanced squamous cell carcinoma (SCC) of the oesophagus

The goal of the NEEDS study is to compare outcomes after neoadjuvant chemoradiotherapy (chemotherapy before surgery) plus esophagectomy to outcomes after definitive chemoradiotherapy (treatment is chosen as the main type of treatment and other treatment options e.g surgery are only used afterwards if they are required) with surveillance and salvage esophagectomy as needed in patients with resectable locally advanced squamous cell carcinoma (SCC) of the esophagus, with the aim to provide generalizeable guidance for future clinical practice

resectable or borderline resectable (per the National Comprehensive Cancer Network (NCCN) criteria) pancreatic adenocarcinoma.

to determine the maximum tolerated dose (MTD) defined by the number of radiotherapy-related ≥ Grade 3 acute toxicities assessed up to 4 weeks post RT. Once the MTD is established, patients will continue to be recruited at that dose level up to a total of 49 patients.

Patients with HER2 positive colorectal cancer that has spread through the body (metastatic) and/or cannot be removed with surgery (unresectable).

The main objective of the study is to find out if tucatinib with other cancer drugs works better than standard of care to treat participants with HER2 positive colorectal cancer. This study will also test what side effects happen when participants take this combination of drugs.

Metastatic refractory pancreatic cancer treated with trametinib and hydroxychloroquine

The goal of this study is to examine if Trametinib and Hydroxychloroquine will improve results for patients with advanced pancreatic cancer compared to standard chemotherapy.

The patients in this study will have advanced human epidermal growth factor 2 (HER2)-positive stomach and esophageal cancers that are no longer treatable with surgery (unresectable) or chemoradiation, and/or have grown or spread to other parts of the body (metastatic)

This study is being done to find out if zanidatamab, when given with chemotherapy plus or minus tislelizumab, is safe and works better than trastuzumab given with chemotherapy.

HER-2 positive metastatic and/or unresectable gastric or gasto-esophageal junction (GEJ) cancer

This study will evaluate the efficacy and safety of trastuzumab deruxtecan (T-DXd), a HER-2 targeting antinbody drug, compared with ramucirumab and paclitaxel (Ram + PTX) in participants with HER2-positive gastric or gastro-esophageal junction (GEJ) cancer who have progressed on or after a trastuzumab-containing regimen and have not received any additional systemic therapy.