DSSG Group: Basket (multiple types)

For older persons with cancer.

The aim of the study is to evaluate the effectiveness and cost-effectiveness of a patient and family navigation intervention (NavCare-EU) for older people with cancer and declining health and their family caregivers in different healthcare systems in Europe

Metastatic or unresectable solid tumour who are eligible to receive Immune Checkpoint Inhibitor’s(ICI’s) alone or in combination with chemotherapy.

The purpose of this study is to compare the faecal microbiome pre and post ICI treatment to look got biomarkers of positive treatment response.

All cancer types known to palliative care services.

A current or prior cancer diagnosis who have clinical insomnia.

This study will examine the efficacy of digital cognitive behavioural therapy for insomnia (dCBT-I) compared to sleep hygiene education.

Cancer Associated Venous Thromboembolism

The purpose of this study is to compare the effect of abelacimab relative to apixaban on venous thromboembolism (VTE) recurrence and bleeding in patients with cancer associated VTE.

For patients with solid tumours or hematologic malignancies who are currently on treatment or in follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

The purpose of this study is to evaluate the long-term safety and efficacy of pembrolizumab (MK-3475) in participants from previous Merck pembrolizumab-based parent studies who transition into this extension study.

All cancers (including metastatic), with the exception of brain cancers.

To assess the safety and effectiveness of a new medication in cancer patients with anorexia and weight loss.

OligoCare: patients with oligometastatic cancer who are planned to receive radical radiation therapy

ReCare: patients treated with high-dose re-irradiation for any solid organ malignancy.

The purpose of the E²-RADIatE platform is to collect real-world data of cancer patients treated with radiotherapy, to support radiotherapy research and to provide evidence of the role of radiation oncology in a multidisciplinary approach.

Patients who are due to receive neoadjuvant chemotherapy or chemoradiation for early-stage locally advanced breast cancer or gastrointestinal cancers.

The main purpose of the study is to determine whether there is a change in the gut microbiome (GM) before and after neo-adjuvant chemotherapy or chemoradiation for early-stage locally advanced Breast or Gastrointestinal (GI) cancers and to examine the association of this change in the GM with pathological response at the time of surgery.

Patients of Childbearing Potential who receive ICIs(Immune checkpoint inhibitors) for Cancer

This study will use a number of tests to assess reproductive parameters in patients 1-2 years after they have received ICI therapy to observe the effect that ICI therapy may have on a patient’s fertility.