About this trial
The study is a multi-centre Phase 3 clinical trial to compare outcomes in patients who receive chemoradiotherapy (chemotherapy and radiotherapy) before surgery versus outcomes in patients who receive chemoradiotherapy with surveillance and oesophagectomy (if it becomes required) in patients with operable locally advanced squamous cell carcinoma (SCC) of the oesophagus.
The study is initiated, organised, and conducted by the Karolinska University Hospital. Karolinska University Hospital is an academically oriented research institution and sponsor of the study. The study is being coordinated by Cancer Trials Ireland in Ireland.
Patient Profile
This study will include 20 Irish patients and 1020 patients globally.
Patients who have been diagnosed with operable locally advanced SCC of the oesophagus will be included in this study.
Where’s this trial being run?
St James’s Hospital
Can I join this study / trial?
The first thing you do is to talk to your doctor and/or the cancer trials research team in your hospital. The contact details for the cancer trials research units in Ireland is here.
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Click HereQuestions?
Here’s a list of questions you may have for your doctor or local cancer research team.
QuestionsSummary Data
| Name: | NEEDS |
|---|---|
| Number: | 20-36 |
| Full Title: | NEoadjuvant chemoradiotherapy for Esophageal squamous cell carcinoma versus Definitive chemoradiotherapy with salvage Surgery as needed (NEEDS Trial) |
| Principal Investigator: | Prof. John Reynolds |
|---|---|
| Type: | Collaborative |
| Sponsor: | Karolinska University Hospital |
| Recruitment Started: |
Global: November 2020 Ireland: February 2024 |
| Global Recruitment Target: | 1020 |
|---|---|
| Ireland Recruitment Target: | 20 |