CADY Sub-Study

About this trial

This is a translational sub-study to the main, original ICORG (CTRIAL-IE) 08-01 CADY-study and includes the:
1. Analysis of the following cardiac biomarkers: high sensitivity Troponin I (hsTnI), B-type Natriuretic Protein (BNP), N-terminal ProBNP (NT-proBNP) and Galectin-3 (Gal-3) on existing blood samples taken within the main Cady study using new, more sensitive test kits.
2. Retrospective collection of Major Adverse Cardiovascular Event (MACE) data on patients enrolled on the main study.
3. Analysis of biomarker results together with the MACE data and the existing LVEF data to assess the predictive capability of the biomarkers.

Patient Profile

No new patients will be recruited to this study. Patients who participated in the CTRIAL-IE (ICORG) 08-01 CADY study on cardiac dysfunction in HER-2 positive breast cancer patients are asked to please read this important data protection notice. In collaboration with Abbott Laboratories, Cancer Trials Ireland is conducting a follow-up sub-study to re-test stored biological samples using advanced biomarker technology and review medical records for cardiovascular outcomes. This research aims to improve the early detection of heart risks in breast cancer patients treated with Trastuzumab. Your data remains securely stored and protected with strict access controls. If you wish to learn more, withdraw consent, or exercise your data rights, click here to read the full notice.

Where’s this trial being run?

Bon Secours Cork, Cork University Hospital, Letterkenny University Hospital, Sligo University Hospital, St James’s Hospital, Tallaght University Hospital, St Vincents University Hospital, University Hospital Limerick, University Hospital Galway, University Hospital Waterford, Mater Misericordiae University Hospital, and Mater Private Hospital

Can I join this study / trial?

The first thing you do is to talk to your doctor and/or the cancer trials research team in your hospital. The contact details for the cancer trials research units in Ireland is here.

Why not Print this page and bring it with you. It will help your doctor and research team advise you.

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For more detailed information

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Questions?

Here’s a list of questions you may have for your doctor or local cancer research team.

Questions

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Summary Data

Name:	CADY Sub-Study
Number:	08-01
Full Title:	“CADY Sub-Study”: Analysis of Biomarker, Cardiotoxicity and Major Adverse Cardiovascular Events data to develop predictive models for cardiotoxicity and MACE in Breast Cancer.

Principal Investigator:	Prof Ray McDermott
Type:	Industry Sponsored
Sponsor:	Cancer Trials Ireland
Recruitment Started:	Global: N/A Ireland: 10-Jun-2008

Global Recruitment Target:	N/A
Ireland Recruitment Target:	480