About this trial
This is a translational sub-study to the main, original ICORG (CTRIAL-IE) 08-01 CADY-study and includes the:
1. Analysis of the following cardiac biomarkers: high sensitivity Troponin I (hsTnI), B-type Natriuretic Protein (BNP), N-terminal ProBNP (NT-proBNP) and Galectin-3 (Gal-3) on existing blood samples taken within the main Cady study using new, more sensitive test kits.
2. Retrospective collection of Major Adverse Cardiovascular Event (MACE) data on patients enrolled on the main study.
3. Analysis of biomarker results together with the MACE data and the existing LVEF data to assess the predictive capability of the biomarkers.
Patient Profile
No new patients will be recruited to this study. The original study involved patients with breast cancer treated with Trastuzumab.
Where’s this trial being run?
Bon Secours Cork, Cork University Hospital, Letterkenny University Hospital, Sligo University Hospital, St James’s Hospital, Tallaght University Hospital, St Vincents University Hospital, University Hospital Limerick, University Hospital Galway, University Hospital Waterford, Mater Misericordiae University Hospital, and Mater Private Hospital
Can I join this study / trial?
The first thing you do is to talk to your doctor and/or the cancer trials research team in your hospital. The contact details for the cancer trials research units in Ireland is here.
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Here’s a list of questions you may have for your doctor or local cancer research team.
QuestionsSummary Data
| Name: | CADY Sub-Study |
|---|---|
| Number: | 08-01 |
| Full Title: | “CADY Sub-Study”: Analysis of Biomarker, Cardiotoxicity and Major Adverse Cardiovascular Events data to develop predictive models for cardiotoxicity and MACE in Breast Cancer. |
| Principal Investigator: | Prof Ray McDermott |
|---|---|
| Type: | Industry Sponsored |
| Sponsor: | Cancer Trials Ireland |
| Recruitment Started: |
Global: N/A Ireland: 10-Jun-2008 |
| Global Recruitment Target: | N/A |
|---|---|
| Ireland Recruitment Target: | 480 |